What is the pathophysiology of liver cirrhosis?




Answer:
Cirrhosis is characterized anatomically by widespread nodules contained by the liver combined with fibrosis. The fibrosis and nodule formation cause distortion of the normal liver architecture which interferes next to blood flow through the liver. Cirrhosis can also lead to an inability of the liver to act its biochemical functions. To understand the pathophysiology of cirrhosis, the everyday anatomy and physiology of the liver must first be briefly reviewed.
chronic inflammation will lead to zone necrosis & bridging fibrosis (both are purely pathological terms), & finally the nouns of Regenerating Nodules (with destruction of the normal liver architecture & obviously liver function) causing increase surrounded by Portal Pressure (due to fibrosis in liver,this increase PP will effect complications like bleeding from the stomach..etc) along near accumilation of waste product surrounded by blood (since the hepaocytes can not perform its function & remove these toxic materials which will accomplish the brain causing Encephalpathy).
This is a massively important & nice subject , you better study it surrounded by details.
Also i like to thank you for asking this query which triggered nice memories of 10 years ago.
in cirrhosis in that is some change within liver cells. liver cell are replaced by fibroblast cells. at hand are regenerative nodules scattered within it. thus liver becomes shrunken,nonfunctional. thus edema, jaundice,lesser infection , bleeding problems set in the body.



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