Pancreatic cancer and inheritance.?
My dad's brother died 2 yrs. ago, and now my dad's other brother is dying from it. What are my dad's and my likelihood of getting it? And are my kids at risk??
Answers: People who have a close relative (a parent, brother or sister) beside pancreatic cancer have an increased risk of developing pancreatic cancer themselves. This risk increases again if you enjoy more than one relative who has have cancer of the pancreas. It is thought that about 1 contained by 10 cancers of the pancreas are due to inheriting an peculiar gene.
As you have a strong ethnic group history, you should perhaps investigate screening - homily to your GP.
Cancer of the pancreas is quite a adjectives cancer. In the UK about 7,000 general public are diagnosed each year, making it the 11th commonest cancer type diagnosed. So while two family connections members have had it might suggest a heritable factor, it's possible that both cases were unsystematic rather than genetic, as most cases are not heritable.
it is not known to be inherent.
diabetics are at higher risk. Read here more or less familial pancreatic cancer.
http://pathology.jhu.edu/pancreas/BasicH...
http://www.pancreasfoundation.org/cgi/cs...
http://www.macgn.org/factsheets/Heredita...
About 10% of cases of pancreatic cancer appear to have heritable as a factor. Choosing to not smoke cigarettes can reduce this risk. I'd look into genetic carrying out tests for the defective gene.
all the best